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April 2021 Medicare Drug List Updates: Ninety-five (95) medications added to 2021 Medicare Part D Drug plan formularies.

Category: Monthly Formulary changes
Published: Apr, 27 2021 05:04:24
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We now have the recently released April 2021 Medicare Part D prescription drug plan formulary (drug lists) data online and included in our Formulary Browser and Q1Rx Drug Finder.

The April formulary updates include the addition of 135 new National Drug Codes (NDCs), representing 95 different prescription drugs, many with multiple strengths.

The formulary updates impact both stand-alone Medicare Part D plans (PDPs) and Medicare Advantage plans with drug coverage (MAPDs).


Highlights of the April 2021 Formulary update include eleven (11) newly-added brand-name drugs

The April drug data updates include forty (40) new brand-name drugs, eleven (11) of which are newly introduced brand-name drugs, some with multiple strengths. These drugs include:
  • ABIRATERONE®,
  • Cystadrops®,
  • Hemady®,
  • Impeklo®,
  • Nyvepria®,
  • ONUREG®,
  • ORGOVYX®,
  • ORLADEYO®,
  • SUTAB®,
  • Travatan Z®, and
  • XYWAV®.

The April 2021 Formulary update includes 26 newly-added generic drugs

The April Medicare Part D drug data also includes 55 new generic medications, 26 of which are newly-introduced generic drugs.  These new generic drugs include:
  • AMABELZ [Mimvey Lo®],
  • AMABELZ [Mimvey®],
  • CHLORDIAZEPOXIDE-CLIDINIUM [Librax®],
  • DICLOFENAC [Voltaren Gel®],
  • DILTIAZEM [Matzim LA®],
  • FYAVOLV [Jevantique®],
  • FYAVOLV [Jinteli 1/5®],
  • HYDROCODONE-IBUPROFEN [Reprexain®],
  • HYDROCODONE-IBUPROFEN [Vicoprofen®],
  • HYDROCODONE-IBUPROFEN [Xylon 10®],
  • ICLEVIA [Setlakin®],
  • ICOSAPENT ETHYL [VASCEPA®],
  • LEVOTHYROXINE [Tirosint®],
  • LYLEQ [Sharobel 28-Day®],
  • MERZEE [Taytulla®],
  • Methoxsalen®],
  • METRONIDAZOLE [Vitazol®],
  • NISOLDIPINE [Sular®],
  • NITAZOXANIDE [Alinia®],
  • NITROFURANTOIN [Furadantin®],
  • NYLIA [Pirmella®],
  • RUFINAMIDE [Banzel®],
  • THEOPHYLLINE [Uniphyl®],
  • TILIA FE [Tri-Legest Fe®],
  • TIMOLOL GEL [Timoptic-XE®], and
  • VYFEMLA [Zenchent®].

You can see our article "April 2021 Drug List Updates: Fifty-five (55) new generic drugs added to many Medicare Part D plan formularies." found at https://Q1News.com/891.html for more about coverage the new generics.

Please note that these new generic and brand-name drugs are not available on all Medicare Part D or Medicare Advantage drug plans - and you can review the chart to see the (often limited) number of plan formularies that now include these drugs.


Reminders about Medicare prescription drug plan formulary changes
  1. Medicare Part D plans (PDPs and MAPDs) can change their formulary or drug list during the year and may drop one of your formulary medication mid-year for specific Medicare-allowable reasons (such as a new generic drug is available), but there are steps you can take if your medication is no longer covered by your prescription drug plan.

  2. Your Medicare Part D plan will notify you if the plan drops a medication you are currently using.

Good to know: What is the NDC?

The NDC or National Drug Code is used to uniquely identify a particular drug, manufacturer, strength, and packaging combination. The NDC is often shown on your prescription bottle as an 11-digit code (see the charts below) or could be formatted as 00000-0000-00 where the first set of numbers identifies the drug manufacturer, the second set of number identifies the product and strength, and the third set of numbers identifies the packaging.  You can read more here: Q1FAQ.com/155


Summary of April 2021 NDC changes

There are many reasons for NDCs to be added to the Medicare Part D program, a summary for all 135 new April 2021 NDCs is as follows:

Reason for NDC Addition Occurrences
New Delivery Form6
New Delivery Form and Strength3
New Drug40
New Drug and Strength49
New Manufacturer1
New Manufacturer and Delivery Form3
New Manufacturer and Strength11
New Manufacturer, Strength and Delivery Form3
New Strength18
New Strength and Packaging1
Total New NDCs135

The following chart details the 135 new manufacturer / drug-strength / packaging combinations (NDCs) that were added to one or more Medicare Part D formularies in the most recent updates -- as you will notices, some drugs are only covered by a few Medicare plans.

You can click on the Drug Name below to go to our Q1Medicare.com Drug Finder (Q1Rx.com) and see the details of how this drug is covered by all Medicare Part D plans (PDPs) in Florida (our example state).  You can then change the state in our search form for details of drug coverage in your service area.


NDC Drug Name Number of
PDP Formularies*		 Number of
MAPD Formularies*		 Notes
00378692191 ABIRATERONE 500 MG TABLET [ZYTIGA] 48 253 New Drug
69543012210 ACARBOSE 100 MG TABLET [Precose] 68 400 New Drug and Strength
69543012010 ACARBOSE 25 MG TABLET [Precose] 68 400 New Drug and Strength
69543012110 ACARBOSE 50 MG TABLET [Precose] 68 400 New Drug and Strength
00023350730 ACUVAIL 0.45% OPHTH SOLUTION DROPERETTE 1 31 New Drug
16110036760 ACZONE 5% GEL 0 1 New Strength and Packaging
00316012830 ALA-CORT 2.5% CREAM (G) [Proctozone-HC] 50 275 New Drug
68180082973 AMABELZ 0.5 MG-0.1 MG TABLET [Mimvey Lo] 32 304 New Drug and Strength
68180083073 AMABELZ 1 MG-0.5 MG TABLET [Mimvey] 43 318 New Drug and Strength
62332019960 ASENAPINE 10 MG SUBLIGUAL TABLET [Saphris] 65 385 New Drug and Strength
51991092860 ASENAPINE 2.5 MG SUBLIGUAL TABLET [Saphris] 65 385 New Drug and Strength
62332019860 ASENAPINE 5 MG SUBLIGUAL TABLET [Saphris] 65 385 New Drug and Strength
68180094702 BETAMETHASONE DP AUG 0.05% OINTMENT [Diprolene] 59 384 New Drug
68462031065 CALCIPOTRIENE 0.005% OINTMENT [Dovonex] 49 336 New Manufacturer and Delivery Form
00781342101 CASPOFUNGIN ACETATE 50 MG VIAL [Cancidas] 64 374 New Drug and Strength
00781342394 CASPOFUNGIN ACETATE 70 MG VIAL [Cancidas] 64 374 New Drug and Strength
61442017130 CEFACLOR 250 MG CAPSULE [Ceclor] 67 395 New Manufacturer and Delivery Form
61442017230 CEFACLOR 500 MG CAPSULE [Ceclor] 68 395 New Manufacturer, Strength and Delivery Form
00093405953 CEFADROXIL 1 GM TABLET [Duricef] 39 280 New Manufacturer, Strength and Delivery Form
11534019701 CHLORDIAZEPOXIDE-CLIDINIUM CAPSULE [Librax] 0 14 New Drug
00078079975 CIPRODEX OTIC SUSPENSION EYE DROPPER 33 136 New Drug
55292041005 CYSTADROPS 0.37% EYE DROPS 35 246 New Drug
68001046741 DAPTOMYCIN 350 MG VIAL [Cubicin RF] 37 237 New Manufacturer and Strength
16714099401 DEFERASIROX 180 MG TABLET [Jadenu] 52 372 New Manufacturer
16714097601 DICLOFENAC SODIUM 1% GEL [Voltaren Gel] 68 400 New Drug
52015070022 DIFICID 40 MG/ML ORAL SUSPENSION 33 279 New Delivery Form and Strength
68682070590 DILTIAZEM 24H ER(LA) 180 MG TABLET [Matzim LA] 37 235 New Drug and Strength
68682070690 DILTIAZEM 24H ER(LA) 240 MG TABLET [Matzim LA] 37 235 New Drug and Strength
68682070790 DILTIAZEM 24H ER(LA) 300 MG TABLET [Matzim LA] 37 235 New Drug and Strength
68682070890 DILTIAZEM 24H ER(LA) 360 MG TABLET [Matzim LA] 37 235 New Drug and Strength
69097055203 DIMETHYL FUMARATE 30D START PK CAPSULE DR [Tecfidera] 40 274 New Manufacturer, Strength and Delivery Form
00378539093 DOXEPIN HCL 3 MG TABLET [Silenor] 36 222 New Drug and Strength
00378539193 DOXEPIN HCL 6 MG TABLET [Silenor] 36 222 New Drug and Strength
58406003204 ENBREL 50 MG/ML SURECLICK PEN INJECTOR 64 397 New Delivery Form
61958220301 EPCLUSA 200 MG-50 MG TABLET 64 259 New Strength
71858040505 FLECTOR 1.3% PATCH TD12 1 38 New Drug
51672138602 FLUOCINONIDE 0.05% CREAM (G) [Lidex] 57 368 New Delivery Form
68180082773 FYAVOLV 0.5 MG-2.5 MCG TABLET [Jevantique] 29 297 New Drug and Strength
68180082873 FYAVOLV 1 MG-5 MCG TABLET [Jinteli 1/5] 29 300 New Drug and Strength
00093803401 GLYBURIDE MICRO 1.5 MG TABLET [Glynase PresTab] 37 232 New Strength
00093803601 GLYBURIDE MICRO 6 MG TABLET [Glynase PresTab] 37 232 New Strength
72893001506 HEMADY 20 MG TABLET 34 123 New Drug
00074012402 HUMIRA(CF) PEN 80 MG/0.8 ML PEN IJ KIT 68 397 New Strength
00603358421 HYDROCODONE-IBUPROFEN 5-200 MG TABLET [Reprexain] 17 243 New Drug and Strength
00603389721 HYDROCODONE-IBUPROFEN 7.5-200 TABLET [Vicoprofen] 51 360 New Drug and Strength
00603358621 HYDROCODONE-IBUPROFEN 10-200 TABLET [Xylon 10] 17 239 New Drug and Strength
00054038663 HYDROMORPHONE 1 MG/ML SOLUTION LIQUID [Dilaudid] 57 343 New Manufacturer and Strength
65862086583 ICLEVIA 0.15 MG-0.03 MG TABLET TBDSPK 3MO [Setlakin] 56 322 New Drug
63020053630 ICLUSIG 10 MG TABLET 68 399 New Strength
63020053330 ICLUSIG 30 MG TABLET 68 399 New Strength
00054050823 ICOSAPENT ETHYL 1 GRAM CAPSULE [VASCEPA] 41 182 New Drug
00065175014 ILEVRO 0.3% OPHTH DROPS EYE DROPPER 43 320 New Drug
49502053735 IMPEKLO 0.05% LOTION MD PMP 0 1 New Drug
72495040128 INTRAROSA 6.5 MG VAG INSERT 6 38 New Drug
51672421108 IVERMECTIN 0.5% LOTION [Sklice] 2 83 New Drug
55111039990 LANSOPRAZOLE DR 30 MG CAPSULE DR [Prevacid] 47 386 New Manufacturer and Strength
71837584305 LEUKINE 250 MCG VIAL 30 231 New Drug
00527495632 LEVOTHYROXINE 100 MCG CAPSULE [Tirosint] 1 30 New Drug and Strength
00527495732 LEVOTHYROXINE 112 MCG CAPSULE [Tirosint] 1 30 New Drug and Strength
00527495832 LEVOTHYROXINE 125 MCG CAPSULE [Tirosint] 1 30 New Drug and Strength
00527495132 LEVOTHYROXINE 13 MCG CAPSULE [Tirosint] 1 31 New Drug and Strength
00527495932 LEVOTHYROXINE 137 MCG CAPSULE [Tirosint] 1 30 New Drug and Strength
00527496032 LEVOTHYROXINE 150 MCG CAPSULE [Tirosint] 1 30 New Drug and Strength
00527496132 LEVOTHYROXINE 175 MCG CAPSULE [Tirosint] 1 30 New Drug and Strength
00527496232 LEVOTHYROXINE 200 MCG CAPSULE [Tirosint] 1 30 New Drug and Strength
00527495232 LEVOTHYROXINE 25 MCG CAPSULE [Tirosint] 1 30 New Drug and Strength
00527495332 LEVOTHYROXINE 50 MCG CAPSULE [Tirosint] 1 30 New Drug and Strength
00527495432 LEVOTHYROXINE 75 MCG CAPSULE [Tirosint] 1 30 New Drug and Strength
00527495532 LEVOTHYROXINE 88 MCG CAPSULE [Tirosint] 1 30 New Drug and Strength
30698045801 LOPRESSOR 50 MG TABLET 3 10 New Strength
50102030013 LYLEQ 0.35 MG TABLET [Sharobel 28-Day] 59 337 New Drug
71225013001 MERZEE 1 MG-20 MCG CAPSULE [Taytulla] 13 107 New Drug
13107008801 METHADONE HCL 5 MG TABLET [Methadose] 68 390 New Manufacturer and Strength
45963032550 METHOXSALEN 10 MG SOFTGEL CAP LQ RAP 37 296 New Drug
00713063337 METRONIDAZOLE 0.75% CREAM (G) [Vitazol] 68 399 New Drug
00469321199 MYCAMINE 100 MG VIAL 8 49 New Drug and Strength
00469325050 MYCAMINE 50 MG VIAL 8 49 New Drug and Strength
69238173002 NAPROXEN 125 MG/5 ML ORAL SUSPENSION [Naprosyn] 37 172 New Manufacturer and Strength
00093100501 NAPROXEN DR 375 MG TABLET DR [EC-Naprosyn] 57 381 New Manufacturer and Strength
69543042610 NAPROXEN DR 500 MG TABLET DR [EC-Naprosyn] 57 381 New Manufacturer and Strength
63020023002 NINLARO 2.3 MG CAPSULE 68 400 New Drug and Strength
63020039002 NINLARO 3 MG CAPSULE 68 400 New Drug and Strength
63020040002 NINLARO 4 MG CAPSULE 68 400 New Drug and Strength
00378209701 NISOLDIPINE ER 17 MG TABLET ER 24H [Sular] 24 213 New Strength
00378209901 NISOLDIPINE ER 34 MG TABLET ER 24H [Sular] 24 213 New Strength
00378209601 NISOLDIPINE ER 8.5 MG TABLET ER 24H [Sular] 24 213 New Strength
64980052603 NITAZOXANIDE 500 MG TABLET [Alinia] 67 396 New Drug
43386045011 NITROFURANTOIN 25 MG/5 ML ORAL SUSPENSION [Furadantin] 34 149 New Drug
65862089788 NYLIA 7-7-7-28 TABLET [Pirmella] 56 343 New Drug
00069032401 NYVEPRIA 6 MG/0.6 ML SYRINGE 4 94 New Drug
75834011950 OFLOXACIN 300 MG TABLET [Floxin] 15 160 New Manufacturer and Strength
75834011250 OFLOXACIN 400 MG TABLET [Floxin] 28 255 New Manufacturer and Strength
59572073014 ONUREG 200 MG TABLET 68 400 New Drug and Strength
59572074014 ONUREG 300 MG TABLET 68 400 New Drug and Strength
72974012001 ORGOVYX 120 MG TABLET 65 380 New Drug
72769010201 ORLADEYO 110 MG CAPSULE 5 76 New Drug and Strength
72769010101 ORLADEYO 150 MG CAPSULE 5 76 New Drug and Strength
55513036955 OTEZLA 28 DAY STARTER PACK TAB DS PK 22 220 New Delivery Form and Strength
55513013760 OTEZLA 30 MG TABLET 22 227 New Delivery Form and Strength
63323081220 OXACILLIN 2 GM VIAL 30 279 New Drug
43386049101 OXYCODONE-ACETAMINOPHEN 5-325 TABLET [Roxicet] 68 400 New Drug
00245164530 PACERONE 400 MG TABLET 57 342 New Strength
65862056090 PANTOPRAZOLE SOD DR 40 MG TABLET DR [Protonix] 68 400 New Manufacturer and Delivery Form
69543045130 POTASSIUM CL 20 MEQ PACKET [Klor-Con] 28 257 New Drug
00069131110 RETACRIT 20,000 UNIT/ML VIAL 41 305 New Strength
00069131810 RETACRIT 20,000 UNIT/2 ML VIAL 41 304 New Strength
69452022384 RUFINAMIDE 40 MG/ML ORAL SUSPENSION [Banzel] 68 394 New Drug
49884072008 SAPROPTERIN 100 MG TABLET SOL [KUVAN] 68 393 New Delivery Form
63323062610 SODIUM CHLORIDE 0.45% SOLUTION IV SOLUTION 67 360 New Strength
52427080901 STALEVO 75 TABLET 0 28 New Strength
52427082701 STALEVO 125 TABLET 0 28 New Strength
52268020101 SUTAB 1.479-0.225-0.188 GM TABLET 4 39 New Drug
Chart continued below.




Chart continued from above.
NDC Drug Name Number of
PDP Formularies*		 Number of
MAPD Formularies*		 Notes
16110083330TAZORAC 0.05% GEL39260New Delivery Form
16110091660TAZORAC 0.1% CREAM (G)06New Delivery Form
68462038001THEOPHYLLINE ER 400 MG TABLET ER 24H [Uniphyl]68399New Drug and Strength
29033000201THEOPHYLLINE ER 600 MG TABLET ER 24H [Uniphyl]68399New Drug and Strength
62756020083TIAGABINE HCL 2 MG TABLET [Gabitril]68400New Manufacturer and Strength
51862089603TILIA FE 28 TABLET [Tri-Legest Fe]51272New Drug
62332054505TIMOLOL 0.25% GEL-SOLUTION SOL-GEL [Timoptic-XE]68387New Drug and Strength
62332054605TIMOLOL 0.5% GEL-SOLUTION SOL-GEL [Timoptic-XE]68387New Drug and Strength
00067434604TRANSDERM-SCOP 1.5 MG (1MG/3D) PATCH TD 31253New Drug
00078094640TRAVATAN Z 0.004% EYE DROPS420New Drug
00173089310TRELEGY ELLIPTA 200-62.5-25 BLST W/DEV59383New Strength
74676590401TRELSTAR 11.25 MG VIAL61378New Drug and Strength
74676590601TRELSTAR 22.5 MG VIAL43299New Drug and Strength
74676590201TRELSTAR 3.75 MG VIAL59373New Drug and Strength
65649000330TRULANCE 3 MG TABLET13184New Drug
68001015600VENLAFAXINE HCL 100 MG TABLET [Effexor]68400New Manufacturer and Strength
51248025099VESICARE LS 5 MG/5 ML ORAL SUSPENSION01New Delivery Form
68180087573VYFEMLA 0.4 MG-0.035 MG TABLET [Zenchent]59350New Drug
68180087373WYMZYA FE 0.4-0.035 MG CHEWABLE TABLET [ZEOSA]35225New Drug
68727015001XYWAV 0.5 GM/ML ORAL SOLUTION25153New Drug
55111062660ZAFIRLUKAST 20 MG TABLET [Accolate]68397New Drug
00245080938ZEMBRACE SYMTOUCH 3 MG/0.5 ML PEN INJECTOR18New Drug
54123090730ZUBSOLV 0.7-0.18 MG SUBLIGUAL TABLET1081New Strength

Our online Formulary Browser and Drug Finder

You can review any Medicare plan formulary using the Q1Medicare.com Formulary Browser found at: FormularyBrowser.com or compare how any medication is covered on all Medicare plans in your Service Area using our Drug Finder found at: Q1Rx.com.



Additional Formulary Drug Change Articles:

Medicare Part D Plan Formulary (Drug Lists) Updates:
June 2024, May 2024, April 2024, September 2023, August 2023, June 2023, May 2023, April 2023, March 2023, February 2023, August 2022, June 2022, May 2022, April 2022, March 2022, February 2022, August 2021, June 2021, May 2021, April 2021, September 2020, August 2020, June 2020, May 2020, April 2020, March 2020, September 2019, July 2019, June 2019, May 2019, April 2019, March 2019, August 2018, July 2018, June 2018, May 2018, April 2018, August 2017, July 2017, May 2017, April 2017, August 2016, July 2016, June 2016, April 2016, March 2016, October 2015, August 2015, July 2015, May 2015, April 2015, August 2014, May 2014, August 2013, June 2013, May 2013, April 2013, August 2012, July 2012, June 2012

Formulary Changes to the Top Medicare Drugs:
June 2024, September 2023, September 2022, September 2021, September 2020, April 2020, September 2019, April 2019, August 2018, April 2018, August 2017, April 2017, August 2016, April 2016, October 2015, April 2015, August 2014, August 2013, April 2013

New Generic Equivalents Added to Formularies:
May 2024, June 2023, February 2023, August 2021, June 2021, May 2021, April 2021, September 2020, August 2020, June 2020, May 2020, April 2020, March 2020, September 2019, July 2019, June 2019, May 2019, April 2019, March 2019, August 2018, July 2018, April 2018, August 2017, July 2017, April 2017, March & April 2016, April & May 2015, August 2014, May 2014


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