The April formulary updates include the addition of 135 new National Drug Codes (NDCs), representing 95 different prescription drugs, many with multiple strengths.
The formulary updates impact both stand-alone Medicare Part D plans (PDPs) and Medicare Advantage plans with drug coverage (MAPDs).
Highlights of the April 2021 Formulary update include eleven (11) newly-added brand-name drugs
The April drug data updates include forty (40) new brand-name drugs, eleven (11) of which are newly introduced brand-name drugs, some with multiple strengths. These drugs include:
- ABIRATERONE®,
- Cystadrops®,
- Hemady®,
- Impeklo®,
- Nyvepria®,
- ONUREG®,
- ORGOVYX®,
- ORLADEYO®,
- SUTAB®,
- Travatan Z®, and
- XYWAV®.
The April 2021 Formulary update includes 26 newly-added generic drugs
The April Medicare Part D drug data also includes 55 new generic medications, 26 of which are newly-introduced generic drugs. These new generic drugs include:
- AMABELZ [Mimvey Lo®],
- AMABELZ [Mimvey®],
- CHLORDIAZEPOXIDE-CLIDINIUM [Librax®],
- DICLOFENAC [Voltaren Gel®],
- DILTIAZEM [Matzim LA®],
- FYAVOLV [Jevantique®],
- FYAVOLV [Jinteli 1/5®],
- HYDROCODONE-IBUPROFEN [Reprexain®],
- HYDROCODONE-IBUPROFEN [Vicoprofen®],
- HYDROCODONE-IBUPROFEN [Xylon 10®],
- ICLEVIA [Setlakin®],
- ICOSAPENT ETHYL [VASCEPA®],
- LEVOTHYROXINE [Tirosint®],
- LYLEQ [Sharobel 28-Day®],
- MERZEE [Taytulla®],
- Methoxsalen®],
- METRONIDAZOLE [Vitazol®],
- NISOLDIPINE [Sular®],
- NITAZOXANIDE [Alinia®],
- NITROFURANTOIN [Furadantin®],
- NYLIA [Pirmella®],
- RUFINAMIDE [Banzel®],
- THEOPHYLLINE [Uniphyl®],
- TILIA FE [Tri-Legest Fe®],
- TIMOLOL GEL [Timoptic-XE®], and
- VYFEMLA [Zenchent®].
You can see our article "April 2021 Drug List Updates: Fifty-five (55) new generic drugs added to many Medicare Part D plan formularies." found at on this site for more about coverage the new generics.
Please note that these new generic and brand-name drugs are not available on all Medicare Part D or Medicare Advantage drug plans - and you can review the chart to see the (often limited) number of plan formularies that now include these drugs.
Reminders about Medicare prescription drug plan formulary changes
- Medicare Part D plans (PDPs and MAPDs) can change their formulary or drug list during the year and may drop one of your formulary medication mid-year for specific Medicare-allowable reasons (such as a new generic drug is available), but there are steps you can take if your medication is no longer covered by your prescription drug plan.
- Your Medicare Part D plan
will notify you if the plan drops a medication you are currently using.
The NDC or National Drug Code is used to uniquely identify a particular drug, manufacturer, strength, and packaging combination. The NDC is often shown on your prescription bottle as an 11-digit code (see the charts below) or could be formatted as 00000-0000-00 where the first set of numbers identifies the drug manufacturer, the second set of number identifies the product and strength, and the third set of numbers identifies the packaging. You can read more on this site
Summary of April 2021 NDC changes
There are many reasons for NDCs to be added to the Medicare Part D program, a summary for all 135 new April 2021 NDCs is as follows:
| Reason for NDC Addition | Occurrences |
| New Delivery Form | 6 |
| New Delivery Form and Strength | 3 |
| New Drug | 40 |
| New Drug and Strength | 49 |
| New Manufacturer | 1 |
| New Manufacturer and Delivery Form | 3 |
| New Manufacturer and Strength | 11 |
| New Manufacturer, Strength and Delivery Form | 3 |
| New Strength | 18 |
| New Strength and Packaging | 1 |
| Total New NDCs | 135 |
The following chart details the 135 new manufacturer / drug-strength / packaging combinations (NDCs) that were added to one or more Medicare Part D formularies in the most recent updates -- as you will notices, some drugs are only covered by a few Medicare plans.
You can click on the Drug Name below to go to our on this site Drug Finder ( on this site) and see the details of how this drug is covered by all Medicare Part D plans (PDPs) in Florida (our example state). You can then change the state in our search form for details of drug coverage in your service area.
| NDC | Drug Name | Number of PDP Formularies* |
Number of MAPD Formularies* |
Notes |
| 00378692191 | ABIRATERONE 500 MG TABLET [ZYTIGA] | 48 | 253 | New Drug |
| 69543012210 | ACARBOSE 100 MG TABLET [Precose] | 68 | 400 | New Drug and Strength |
| 69543012010 | ACARBOSE 25 MG TABLET [Precose] | 68 | 400 | New Drug and Strength |
| 69543012110 | ACARBOSE 50 MG TABLET [Precose] | 68 | 400 | New Drug and Strength |
| 00023350730 | ACUVAIL 0.45% OPHTH SOLUTION DROPERETTE | 1 | 31 | New Drug |
| 16110036760 | ACZONE 5% GEL | 0 | 1 | New Strength and Packaging |
| 00316012830 | ALA-CORT 2.5% CREAM (G) [Proctozone-HC] | 50 | 275 | New Drug |
| 68180082973 | AMABELZ 0.5 MG-0.1 MG TABLET [Mimvey Lo] | 32 | 304 | New Drug and Strength |
| 68180083073 | AMABELZ 1 MG-0.5 MG TABLET [Mimvey] | 43 | 318 | New Drug and Strength |
| 62332019960 | ASENAPINE 10 MG SUBLIGUAL TABLET [Saphris] | 65 | 385 | New Drug and Strength |
| 51991092860 | ASENAPINE 2.5 MG SUBLIGUAL TABLET [Saphris] | 65 | 385 | New Drug and Strength |
| 62332019860 | ASENAPINE 5 MG SUBLIGUAL TABLET [Saphris] | 65 | 385 | New Drug and Strength |
| 68180094702 | BETAMETHASONE DP AUG 0.05% OINTMENT [Diprolene] | 59 | 384 | New Drug |
| 68462031065 | CALCIPOTRIENE 0.005% OINTMENT [Dovonex] | 49 | 336 | New Manufacturer and Delivery Form |
| 00781342101 | CASPOFUNGIN ACETATE 50 MG VIAL [Cancidas] | 64 | 374 | New Drug and Strength |
| 00781342394 | CASPOFUNGIN ACETATE 70 MG VIAL [Cancidas] | 64 | 374 | New Drug and Strength |
| 61442017130 | CEFACLOR 250 MG CAPSULE [Ceclor] | 67 | 395 | New Manufacturer and Delivery Form |
| 61442017230 | CEFACLOR 500 MG CAPSULE [Ceclor] | 68 | 395 | New Manufacturer, Strength and Delivery Form |
| 00093405953 | CEFADROXIL 1 GM TABLET [Duricef] | 39 | 280 | New Manufacturer, Strength and Delivery Form |
| 11534019701 | CHLORDIAZEPOXIDE-CLIDINIUM CAPSULE [Librax] | 0 | 14 | New Drug |
| 00078079975 | CIPRODEX OTIC SUSPENSION EYE DROPPER | 33 | 136 | New Drug |
| 55292041005 | CYSTADROPS 0.37% EYE DROPS | 35 | 246 | New Drug |
| 68001046741 | DAPTOMYCIN 350 MG VIAL [Cubicin RF] | 37 | 237 | New Manufacturer and Strength |
| 16714099401 | DEFERASIROX 180 MG TABLET [Jadenu] | 52 | 372 | New Manufacturer |
| 16714097601 | DICLOFENAC SODIUM 1% GEL [Voltaren Gel] | 68 | 400 | New Drug |
| 52015070022 | DIFICID 40 MG/ML ORAL SUSPENSION | 33 | 279 | New Delivery Form and Strength |
| 68682070590 | DILTIAZEM 24H ER(LA) 180 MG TABLET [Matzim LA] | 37 | 235 | New Drug and Strength |
| 68682070690 | DILTIAZEM 24H ER(LA) 240 MG TABLET [Matzim LA] | 37 | 235 | New Drug and Strength |
| 68682070790 | DILTIAZEM 24H ER(LA) 300 MG TABLET [Matzim LA] | 37 | 235 | New Drug and Strength |
| 68682070890 | DILTIAZEM 24H ER(LA) 360 MG TABLET [Matzim LA] | 37 | 235 | New Drug and Strength |
| 69097055203 | DIMETHYL FUMARATE 30D START PK CAPSULE DR [Tecfidera] | 40 | 274 | New Manufacturer, Strength and Delivery Form |
| 00378539093 | DOXEPIN HCL 3 MG TABLET [Silenor] | 36 | 222 | New Drug and Strength |
| 00378539193 | DOXEPIN HCL 6 MG TABLET [Silenor] | 36 | 222 | New Drug and Strength |
| 58406003204 | ENBREL 50 MG/ML SURECLICK PEN INJECTOR | 64 | 397 | New Delivery Form |
| 61958220301 | EPCLUSA 200 MG-50 MG TABLET | 64 | 259 | New Strength |
| 71858040505 | FLECTOR 1.3% PATCH TD12 | 1 | 38 | New Drug |
| 51672138602 | FLUOCINONIDE 0.05% CREAM (G) [Lidex] | 57 | 368 | New Delivery Form |
| 68180082773 | FYAVOLV 0.5 MG-2.5 MCG TABLET [Jevantique] | 29 | 297 | New Drug and Strength |
| 68180082873 | FYAVOLV 1 MG-5 MCG TABLET [Jinteli 1/5] | 29 | 300 | New Drug and Strength |
| 00093803401 | GLYBURIDE MICRO 1.5 MG TABLET [Glynase PresTab] | 37 | 232 | New Strength |
| 00093803601 | GLYBURIDE MICRO 6 MG TABLET [Glynase PresTab] | 37 | 232 | New Strength |
| 72893001506 | HEMADY 20 MG TABLET | 34 | 123 | New Drug |
| 00074012402 | HUMIRA(CF) PEN 80 MG/0.8 ML PEN IJ KIT | 68 | 397 | New Strength |
| 00603358421 | HYDROCODONE-IBUPROFEN 5-200 MG TABLET [Reprexain] | 17 | 243 | New Drug and Strength |
| 00603389721 | HYDROCODONE-IBUPROFEN 7.5-200 TABLET [Vicoprofen] | 51 | 360 | New Drug and Strength |
| 00603358621 | HYDROCODONE-IBUPROFEN 10-200 TABLET [Xylon 10] | 17 | 239 | New Drug and Strength |
| 00054038663 | HYDROMORPHONE 1 MG/ML SOLUTION LIQUID [Dilaudid] | 57 | 343 | New Manufacturer and Strength |
| 65862086583 | ICLEVIA 0.15 MG-0.03 MG TABLET TBDSPK 3MO [Setlakin] | 56 | 322 | New Drug |
| 63020053630 | ICLUSIG 10 MG TABLET | 68 | 399 | New Strength |
| 63020053330 | ICLUSIG 30 MG TABLET | 68 | 399 | New Strength |
| 00054050823 | ICOSAPENT ETHYL 1 GRAM CAPSULE [VASCEPA] | 41 | 182 | New Drug |
| 00065175014 | ILEVRO 0.3% OPHTH DROPS EYE DROPPER | 43 | 320 | New Drug |
| 49502053735 | IMPEKLO 0.05% LOTION MD PMP | 0 | 1 | New Drug |
| 72495040128 | INTRAROSA 6.5 MG VAG INSERT | 6 | 38 | New Drug |
| 51672421108 | IVERMECTIN 0.5% LOTION [Sklice] | 2 | 83 | New Drug |
| 55111039990 | LANSOPRAZOLE DR 30 MG CAPSULE DR [Prevacid] | 47 | 386 | New Manufacturer and Strength |
| 71837584305 | LEUKINE 250 MCG VIAL | 30 | 231 | New Drug |
| 00527495632 | LEVOTHYROXINE 100 MCG CAPSULE [Tirosint] | 1 | 30 | New Drug and Strength |
| 00527495732 | LEVOTHYROXINE 112 MCG CAPSULE [Tirosint] | 1 | 30 | New Drug and Strength |
| 00527495832 | LEVOTHYROXINE 125 MCG CAPSULE [Tirosint] | 1 | 30 | New Drug and Strength |
| 00527495132 | LEVOTHYROXINE 13 MCG CAPSULE [Tirosint] | 1 | 31 | New Drug and Strength |
| 00527495932 | LEVOTHYROXINE 137 MCG CAPSULE [Tirosint] | 1 | 30 | New Drug and Strength |
| 00527496032 | LEVOTHYROXINE 150 MCG CAPSULE [Tirosint] | 1 | 30 | New Drug and Strength |
| 00527496132 | LEVOTHYROXINE 175 MCG CAPSULE [Tirosint] | 1 | 30 | New Drug and Strength |
| 00527496232 | LEVOTHYROXINE 200 MCG CAPSULE [Tirosint] | 1 | 30 | New Drug and Strength |
| 00527495232 | LEVOTHYROXINE 25 MCG CAPSULE [Tirosint] | 1 | 30 | New Drug and Strength |
| 00527495332 | LEVOTHYROXINE 50 MCG CAPSULE [Tirosint] | 1 | 30 | New Drug and Strength |
| 00527495432 | LEVOTHYROXINE 75 MCG CAPSULE [Tirosint] | 1 | 30 | New Drug and Strength |
| 00527495532 | LEVOTHYROXINE 88 MCG CAPSULE [Tirosint] | 1 | 30 | New Drug and Strength |
| 30698045801 | LOPRESSOR 50 MG TABLET | 3 | 10 | New Strength |
| 50102030013 | LYLEQ 0.35 MG TABLET [Sharobel 28-Day] | 59 | 337 | New Drug |
| 71225013001 | MERZEE 1 MG-20 MCG CAPSULE [Taytulla] | 13 | 107 | New Drug |
| 13107008801 | METHADONE HCL 5 MG TABLET [Methadose] | 68 | 390 | New Manufacturer and Strength |
| 45963032550 | METHOXSALEN 10 MG SOFTGEL CAP LQ RAP | 37 | 296 | New Drug |
| 00713063337 | METRONIDAZOLE 0.75% CREAM (G) [Vitazol] | 68 | 399 | New Drug |
| 00469321199 | MYCAMINE 100 MG VIAL | 8 | 49 | New Drug and Strength |
| 00469325050 | MYCAMINE 50 MG VIAL | 8 | 49 | New Drug and Strength |
| 69238173002 | NAPROXEN 125 MG/5 ML ORAL SUSPENSION [Naprosyn] | 37 | 172 | New Manufacturer and Strength |
| 00093100501 | NAPROXEN DR 375 MG TABLET DR [EC-Naprosyn] | 57 | 381 | New Manufacturer and Strength |
| 69543042610 | NAPROXEN DR 500 MG TABLET DR [EC-Naprosyn] | 57 | 381 | New Manufacturer and Strength |
| 63020023002 | NINLARO 2.3 MG CAPSULE | 68 | 400 | New Drug and Strength |
| 63020039002 | NINLARO 3 MG CAPSULE | 68 | 400 | New Drug and Strength |
| 63020040002 | NINLARO 4 MG CAPSULE | 68 | 400 | New Drug and Strength |
| 00378209701 | NISOLDIPINE ER 17 MG TABLET ER 24H [Sular] | 24 | 213 | New Strength |
| 00378209901 | NISOLDIPINE ER 34 MG TABLET ER 24H [Sular] | 24 | 213 | New Strength |
| 00378209601 | NISOLDIPINE ER 8.5 MG TABLET ER 24H [Sular] | 24 | 213 | New Strength |
| 64980052603 | NITAZOXANIDE 500 MG TABLET [Alinia] | 67 | 396 | New Drug |
| 43386045011 | NITROFURANTOIN 25 MG/5 ML ORAL SUSPENSION [Furadantin] | 34 | 149 | New Drug |
| 65862089788 | NYLIA 7-7-7-28 TABLET [Pirmella] | 56 | 343 | New Drug |
| 00069032401 | NYVEPRIA 6 MG/0.6 ML SYRINGE | 4 | 94 | New Drug |
| 75834011950 | OFLOXACIN 300 MG TABLET [Floxin] | 15 | 160 | New Manufacturer and Strength |
| 75834011250 | OFLOXACIN 400 MG TABLET [Floxin] | 28 | 255 | New Manufacturer and Strength |
| 59572073014 | ONUREG 200 MG TABLET | 68 | 400 | New Drug and Strength |
| 59572074014 | ONUREG 300 MG TABLET | 68 | 400 | New Drug and Strength |
| 72974012001 | ORGOVYX 120 MG TABLET | 65 | 380 | New Drug |
| 72769010201 | ORLADEYO 110 MG CAPSULE | 5 | 76 | New Drug and Strength |
| 72769010101 | ORLADEYO 150 MG CAPSULE | 5 | 76 | New Drug and Strength |
| 55513036955 | OTEZLA 28 DAY STARTER PACK TAB DS PK | 22 | 220 | New Delivery Form and Strength |
| 55513013760 | OTEZLA 30 MG TABLET | 22 | 227 | New Delivery Form and Strength |
| 63323081220 | OXACILLIN 2 GM VIAL | 30 | 279 | New Drug |
| 43386049101 | OXYCODONE-ACETAMINOPHEN 5-325 TABLET [Roxicet] | 68 | 400 | New Drug |
| 00245164530 | PACERONE 400 MG TABLET | 57 | 342 | New Strength |
| 65862056090 | PANTOPRAZOLE SOD DR 40 MG TABLET DR [Protonix] | 68 | 400 | New Manufacturer and Delivery Form |
| 69543045130 | POTASSIUM CL 20 MEQ PACKET [Klor-Con] | 28 | 257 | New Drug |
| 00069131110 | RETACRIT 20,000 UNIT/ML VIAL | 41 | 305 | New Strength |
| 00069131810 | RETACRIT 20,000 UNIT/2 ML VIAL | 41 | 304 | New Strength |
| 69452022384 | RUFINAMIDE 40 MG/ML ORAL SUSPENSION [Banzel] | 68 | 394 | New Drug |
| 49884072008 | SAPROPTERIN 100 MG TABLET SOL [KUVAN] | 68 | 393 | New Delivery Form |
| 63323062610 | SODIUM CHLORIDE 0.45% SOLUTION IV SOLUTION | 67 | 360 | New Strength |
| 52427080901 | STALEVO 75 TABLET | 0 | 28 | New Strength |
| 52427082701 | STALEVO 125 TABLET | 0 | 28 | New Strength |
| 52268020101 | SUTAB 1.479-0.225-0.188 GM TABLET | 4 | 39 | New Drug |
Chart continued from above.
| NDC | Drug Name | Number of PDP Formularies* |
Number of MAPD Formularies* |
Notes |
| 16110083330 | TAZORAC 0.05% GEL | 39 | 260 | New Delivery Form |
| 16110091660 | TAZORAC 0.1% CREAM (G) | 0 | 6 | New Delivery Form |
| 68462038001 | THEOPHYLLINE ER 400 MG TABLET ER 24H [Uniphyl] | 68 | 399 | New Drug and Strength |
| 29033000201 | THEOPHYLLINE ER 600 MG TABLET ER 24H [Uniphyl] | 68 | 399 | New Drug and Strength |
| 62756020083 | TIAGABINE HCL 2 MG TABLET [Gabitril] | 68 | 400 | New Manufacturer and Strength |
| 51862089603 | TILIA FE 28 TABLET [Tri-Legest Fe] | 51 | 272 | New Drug |
| 62332054505 | TIMOLOL 0.25% GEL-SOLUTION SOL-GEL [Timoptic-XE] | 68 | 387 | New Drug and Strength |
| 62332054605 | TIMOLOL 0.5% GEL-SOLUTION SOL-GEL [Timoptic-XE] | 68 | 387 | New Drug and Strength |
| 00067434604 | TRANSDERM-SCOP 1.5 MG (1MG/3D) PATCH TD 3 | 12 | 53 | New Drug |
| 00078094640 | TRAVATAN Z 0.004% EYE DROPS | 4 | 20 | New Drug |
| 00173089310 | TRELEGY ELLIPTA 200-62.5-25 BLST W/DEV | 59 | 383 | New Strength |
| 74676590401 | TRELSTAR 11.25 MG VIAL | 61 | 378 | New Drug and Strength |
| 74676590601 | TRELSTAR 22.5 MG VIAL | 43 | 299 | New Drug and Strength |
| 74676590201 | TRELSTAR 3.75 MG VIAL | 59 | 373 | New Drug and Strength |
| 65649000330 | TRULANCE 3 MG TABLET | 13 | 184 | New Drug |
| 68001015600 | VENLAFAXINE HCL 100 MG TABLET [Effexor] | 68 | 400 | New Manufacturer and Strength |
| 51248025099 | VESICARE LS 5 MG/5 ML ORAL SUSPENSION | 0 | 1 | New Delivery Form |
| 68180087573 | VYFEMLA 0.4 MG-0.035 MG TABLET [Zenchent] | 59 | 350 | New Drug |
| 68180087373 | WYMZYA FE 0.4-0.035 MG CHEWABLE TABLET [ZEOSA] | 35 | 225 | New Drug |
| 68727015001 | XYWAV 0.5 GM/ML ORAL SOLUTION | 25 | 153 | New Drug |
| 55111062660 | ZAFIRLUKAST 20 MG TABLET [Accolate] | 68 | 397 | New Drug |
| 00245080938 | ZEMBRACE SYMTOUCH 3 MG/0.5 ML PEN INJECTOR | 1 | 8 | New Drug |
| 54123090730 | ZUBSOLV 0.7-0.18 MG SUBLIGUAL TABLET | 10 | 81 | New Strength |
Our online Formulary Browser and Drug Finder
You can review any Medicare plan formulary using the on this site Formulary Browser found at: FormularyBrowser.com or compare how any medication is covered on all Medicare plans in your Service Area using our Drug Finder found at on this site.