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November 2025 Drug List Updates: Thirty-four (34) new generic drugs added to many 2026 Medicare Part D plan formularies.

Monthly Formulary changes · published Nov 20, 2025

As you may know, Medicare Part D prescription drug plans update their plan formularies (drug lists) throughout the year and the November 2025 updates to the 2026 Medicare Part D formularies includes sixty-five (65) new drugs, thirty-four (34) of which are generics - with a total of fifty-seven (75) new generic equivalents (variations of manufacturer, drug-strength, and packaging).

Of the thirty-four (34) new generic medications, twelve (12) are newly-introduced generic drugs.  These new generic drugs include:
  • ABIGALE [MIMVEY®],
  • BUCAPSOL,
  • DIPYRIDAMOLE [PERSANTINE®],
  • FLUTICASONE ELLIPTA [ARNUITY ELLIPTA®],
  • ORQUIDEA [SHAROBEL 28-DAY®],
  • PERAMPANEL [FYCOMPA®],
  • PILOCARPINE [VUITY®],
  • SACUBITRIL-VALSARTAN [ENTRESTO®],
  • SITAGLIPTIN-METFORM ER [ZITUVIMET XR®],
  • SRONYX [VIENVA®],
  • TOPIRAMATE [EPRONTIA®], and 
  • JAYTHARI.

Please note that these new generic drugs are not available on all Medicare Part D (PDP) or Medicare Advantage plan (MAPD) formularies.  You can review the chart below to see the (often limited) number of plan formularies that now include these drugs.

The following chart details the fifty-seven (57) new generic manufacturer / drug-strength / packaging combinations (NDCs) that were added to one or more Medicare Part D formularies in the most recent updates -- as you will notices, some drugs are only covered by a few Medicare plans.



Generic Drug Equivalent [Brand-Name Drug]

Number of
PDP
Formularies*

Number of
MAPD
Formularies*
ABIGALE 1 MG-0.5 MG TABLET [Mimvey] 29 248
BISOPROLOL FUMARATE 2.5 MG TABLET 9 92
BLISOVI FE 1.5-30 TABLET [Microgestin Fe 1.5/30] 34 260
BUCAPSOL 15 MG CAPSULE 0 3
CARBAMAZEPINE 100 MG/5 ML ORAL SUSPENSION [Tegretol] 35 299
DICYCLOMINE 40 MG TABLET 0 4
DIPYRIDAMOLE 25 MG TABLET [Persantine] 15 231
DIPYRIDAMOLE 50 MG TABLET [Persantine] 15 231
DIPYRIDAMOLE 75 MG TABLET [Persantine] 15 231
ENOXAPARIN 150 MG/ML SYRINGE [Lovenox] 35 299
ENOXAPARIN 80 MG/0.8 ML SYR SYRINGE [Lovenox] 35 299
FLUOROURACIL 0.5% CREAM (G) [Carac] 2 58
FLUTICASONE ELLIPTA 100 MCG INH BLST W/DEV [ARNUITY ELLIPTA] 0 5
FLUTICASONE ELLIPTA 200 MCG INH BLST W/DEV [ARNUITY ELLIPTA] 0 5
FLUTICASONE ELLIPTA 50 MCG INH BLST W/DEV [ARNUITY ELLIPTA] 0 5
IBUPROFEN 300 MG TABLET 0 2
JAYTHARI 18 MG TABLET 0 12
JAYTHARI 30 MG TABLET 0 12
JAYTHARI 36 MG TABLET 0 12
JAYTHARI 6 MG TABLET 0 12
KLOR-CON M10 MEQ TABLET [Klotrix] 35 232
MERCAPTOPURINE 20 MG/ML ORAL SUSPENSION [PURIXAN] 35 299
MICROGESTIN FE 1-20 TABLET [Tarina Fe 1/20] 33 288
MICROGESTIN FE 1.5-30 TABLET 33 281
NECON 0.5-35-28 TABLET [WERA] 32 211
NORETH-EE-FE 1-0.02(24)-75 CAPSULE [Taytulla] 2 25
ORQUIDEA 0.35 MG TABLET [Sharobel 28-Day] 34 272
PERAMPANEL 10 MG TABLET [Fycompa] 33 295
PERAMPANEL 12 MG TABLET [Fycompa] 33 295
PERAMPANEL 2 MG TABLET [Fycompa] 33 295
PERAMPANEL 4 MG TABLET [Fycompa] 33 295
PERAMPANEL 6 MG TABLET [Fycompa] 33 295
PERAMPANEL 8 MG TABLET [Fycompa] 33 295
PHENYTOIN 125 MG/5 ML ORAL SUSPENSION [Dilantin] 35 299
PILOCARPINE HCL 1.25% EYE DROPS [Vuity] 0 16
PROPAFENONE HCL 150 MG TABLET [Rythmol] 35 299
RIVAROXABAN 1 MG/ML ORAL SUSPENSION [Xarelto] 31 235
SACUBITRIL-VALSARTAN 24-26 MG TABLET [Entresto] 35 283
SACUBITRIL-VALSARTAN 49-51 MG TABLET [Entresto] 35 283
SACUBITRIL-VALSARTAN 97-103 MG TABLET [Entresto] 35 283
SERTRALINE 150 MG CAPSULE 0 9
SERTRALINE 200 MG CAPSULE 0 9
SITAGLIPTIN-METFORM ER 100-1,000 TBMP 24HR [Zituvimet XR] 0 3
SITAGLIPTIN-METFORM ER 50-1,000 TBMP 24HR [Zituvimet XR] 0 3
SITAGLIPTIN-METFORM ER 50-500 TBMP 24HR [Zituvimet XR] 0 3
SRONYX 0.10-0.02 MG TABLET [Vienva] 33 278
TOLVAPTAN 15 MG TABLET [JYNARQUE] 29 221
TOLVAPTAN 30 MG TABLET [JYNARQUE] 29 221
TOPIRAMATE 25 MG/ML SOLUTION [EPRONTIA] 35 299
USTEKINUMAB-AEKN 45 MG SYRINGE [Yesintek] 19 75
USTEKINUMAB-AEKN 90 MG/ML SYRINGE [Yesintek] 19 75
VANCOMYCIN HCL 250 MG CAPSULE [Vancocin] 35 298
VERAPAMIL ER 120 MG CAPSULE 24H PEL [Verelan] 30 289
VERAPAMIL ER 180 MG CAPSULE 24H PEL [Verelan] 30 289
VERAPAMIL ER 240 MG CAPSULE 24H PEL [Verelan] 30 289
VERAPAMIL SR 360 MG CAPSULE 24H PEL [Verelan] 23 252




*The number of formularies counts the unique formularies that offer this medication. As a note, the same formulary can be used by one or many different Medicare Part D plans. The same formulary can be used by both PDP and MAPD plans.

What Could the Addition of New Generic Drugs Mean to You?

  • You may be able to save money by switching from the brand-name drug to its generic equivalent – with your prescriber’s approval and a new prescription. Please note, you will need to look carefully at coverage costs as we have found that many generics are being offered on the same tier as their brand-name equivalent or the generics do not have a significantly lower retail price.

  • Your brand-name drug may no longer be available if a generic is now available. Based on past experience, you may find that many Medicare Part D plans discontinue coverage for the brand-name drug in the months following the introduction of the generic equivalent - or your plan may immediately drop the brand-name drug now that the generic is being introduced.

    If you have received notice from your Medicare Part D plan that your brand-name medication will be dropped, you should speak with your prescriber to determine if you can take the generic equivalent or if you must continue taking the brand-name drug, you will need to ask your plan for a formulary exception to continue coverage for your brand-name drug.
As a note, both our Formulary Browser (you can view all the drugs covered by a single 2026 Medicare prescription drug plan) and our the drug finder Drug Finder (you can view all the 2026 Medicare drug plans covering a single drug) have been updated with the November 2025 Medicare Part D formulary data.

Additional Formulary Drug Change Articles:

Medicare Part D Plan Formulary (Drug Lists) Updates:
June 2026, May 2026, March-April 2026, February 2026, 2026 Rx: November 2025, August 2025, July 2025, June 2025, April 2025, March 2025, June 2024, May 2024, April 2024, September 2023, August 2023, June 2023, May 2023, April 2023, March 2023, February 2023, August 2022, June 2022, May 2022, April 2022, March 2022, February 2022, August 2021, June 2021, May 2021, April 2021, September 2020, August 2020, June 2020, May 2020, April 2020, March 2020, September 2019, July 2019, June 2019, May 2019, April 2019, March 2019, August 2018, July 2018, June 2018, May 2018, April 2018, August 2017, July 2017, May 2017, April 2017, August 2016, July 2016, June 2016, April 2016, March 2016, October 2015, August 2015, July 2015, May 2015, April 2015, August 2014, May 2014, August 2013, June 2013, May 2013, April 2013, August 2012, July 2012, June 2012

New Generic Equivalents Added to Formularies:
2026 Gnrcs: November 2025 May 2024, June 2023, February 2023, August 2021, June 2021, May 2021, April 2021, September 2020, August 2020, June 2020, May 2020, April 2020, March 2020, September 2019, July 2019, June 2019, May 2019, April 2019, March 2019, August 2018, July 2018, April 2018, August 2017, July 2017, April 2017, March & April 2016, April & May 2015, August 2014, May 2014