The November formulary updates include the addition of 91 new National Drug Codes (NDCs), representing 65 different prescription drugs, many with multiple strengths.
The formulary updates impact both stand-alone Medicare Part D plans (PDPs) and Medicare Advantage plans with drug coverage (MAPDs).
Highlights of the November 2025 Formulary updates include twenty (20) newly-introduced brand-name drugs
The November drug data updates include thirty-one (31) new brand-name drugs, twenty (20) of which are newly introduced brand-name drugs, some with multiple strengths. These drugs include:
- ANZUPGO®,
- BOMYNTRA®,
- BRINSUPRI®,
- CLINOLIPID®,
- CONEXXENCE®,
- EDURANT PED®,
- EKTERLY®,
- HERNEXEOS®,
- IBTROZI®,
- LEQSELVI®,
- MERILOG SOLOSTAR®,
- MERILOG®,
- MODEYSO®,
- OSENVELT®,
- PENMENVY®,
- PRAMOSONE®,
- PRURADIK®,
- PYZCHIVA®,
- STOBOCLO®, and
- ZELSUVMI®.
The November 2025 Formulary updates include twelve (12) newly-added generic drugs
The November Medicare Part D drug data also includes thirty-four (34) new generic medications, twelve (12) of which are newly-introduced generic drugs. These drugs include:
- ABIGALE [MIMVEY®],
- BUCAPSOL,
- DIPYRIDAMOLE [PERSANTINE®],
- FLUTICASONE ELLIPTA [ARNUITY ELLIPTA®],
- ORQUIDEA [SHAROBEL 28-DAY®],
- PERAMPANEL [FYCOMPA®],
- PILOCARPINE [VUITY®],
- SACUBITRIL-VALSARTAN [ENTRESTO®],
- SITAGLIPTIN-METFORM ER [ZITUVIMET XR®],
- SRONYX [VIENVA®],
- TOPIRAMATE [EPRONTIA®], and
- JAYTHARI.
You can read more about the new generics in our article: November 2025 Medicare Drug List Updates: Sixty-five (65) medications added to the 2026 Medicare Part D Drug plan formularies.
Reminders about Medicare prescription drug plan formulary changes
- Medicare Part D plans (PDPs and MAPDs) can change their formulary or drug list during the year and may drop one of your formulary medication mid-year for specific Medicare-allowable reasons (such as a new generic drug is available), but there are steps you can take if your medication is no longer covered by your prescription drug plan.
- In most cases, your Medicare Part D plan
will notify you if the plan drops a medication you are currently using.
The NDC or National Drug Code is used to uniquely identify a particular drug, manufacturer, strength, and packaging combination. The NDC is often shown on your prescription bottle as an 11-digit code (see the charts below) or could be formatted as 00000-0000-00 where the first set of numbers identifies the drug manufacturer, the second set of number identifies the product and strength, and the third set of numbers identifies the packaging. You can read more on this site
Summary of November 2025 NDC changes
There are many reasons for NDCs to be added to the Medicare Part D program, a summary for all 91 new November 2025 NDCs is as follows:
| Reason for NDC Addition | Occurrences |
| New Delivery Form and Strength | 1 |
| New Drug | 39 |
| New Drug and Packaging | 2 |
| New Drug and Strength | 26 |
| New Drug, Delivery Form and Strength | 2 |
| New Manufacturer and Strength | 5 |
| New Manufacturer, Delivery Form and Strength | 6 |
| New Strength | 10 |
| Grand Total | 91 |
The following chart details the 91 new manufacturer / drug-strength / packaging combinations (NDCs) that were added to one or more Medicare Part D formularies in the most recent updates -- as you will notices, some drugs are only covered by a few Medicare plans.
You can click on the Drug Name below to go to our on this site Drug Finder ( on this site) and see the details of how this drug is covered by all Medicare Part D plans (PDPs) in Florida (our example state). You can then change the state in our search form for details of drug coverage in your service area.
- Ask your prescriber about trying the generic.
- Check for an alternative formulary drug.
- Ask your plan to cover a non-formulary drug.
You will need to work with your doctor or prescriber to explain why you are not able to use the generic medication or why no other formulary drug is acceptable. If your formulary exception is denied, you have the right to appeal your plan’s decision.
- Consider using a Special Enrollment Period and move to another Medicare plan that provides coverage of all your prescription and health needs.
Our online Formulary Browser and Drug Finder
You can review any Medicare plan formulary using the on this site Formulary Browser found at: FormularyBrowser.com or compare how any medication is covered on all Medicare plans in your Service Area using our Drug Finder found at on this site.